When substances are stabilized by temperature control, the provisions of 2.2.41.1.21, 7.1.7, special provision V8 of Chapter 7.2 of ADR, special provision S4 of Chapter 8.5 of ADR and the requirements of Chapter 9.6 of ADR apply. When chemical stabilization is employed, the person offering the packaging, IBC or tank for carriage shall ensure that the level of stabilization is sufficient to prevent the substance in the packaging, IBC or tank from dangerous polymerization at a bulk mean loading temperature of 50 °C, or, in the case of a portable tank, 45 °C. Where chemical stabilization becomes ineffective at lower temperatures within the anticipated duration of carriage, temperature control is required. In making this determination factors to be taken into consideration include, but are not limited to, the capacity and geometry of the packaging, IBC or tank and the effect of any insulation present, the temperature of the substance when offered for carriage, the duration of the journey and the ambient temperature conditions typically encountered in the journey (considering also the season of year), the effectiveness and other properties of the stabilizer employed, applicable operational controls imposed by regulation (e.g. requirements to protect from sources of heat, including other cargo carried at a temperature above ambient) and any other relevant factors.